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It first began appearing in the early to mid 2000s, and started seeing common usage a few years ago.

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Despite the unknowns, there are some things that is a stimulant drug that has some entactogenic (huggy/lovey) effects.

It belongs to the chemical class of substituted amphetamines, a sub-category of the substituted phenethylamine class.

Chemically, it differs from amphetamine only by a flourine atom substitution at the 4 position of the phenethylamine backbone’s benzene ring.

This is fancy talk for “4-FA is only one flourine atom different from amphetamine”.

4-FA can be identified with a sky blue reaction on the Mandelin reagent, orange with the Liebermann reagent.

4-FA acts as a releasing agent and reuptake inhibitor for serotonin, dopamine, and norepinephrine.

This means that these neurotransmitters get both pushed out of the presynaptic neuron into the synaptic cleft, where they activate the corresponding receptors on the post-synaptic neuron, and they are also being blocked from being taken back up to the presynaptic neuron by the drug molecule’s affinity to the transporter proteins on the reuptake pump of the presynaptic neuron, causing these neurotransmitters to activate the receptors to a much greater extent than usual.

Essentially, they are pushed out and blocked from being re-used.

The way in which it compares to MDMA and amphetamine is that MDMA mostly acts as a releasing agent and reuptake inhibitor for serotonin, while amphetamine acts mostly as a releasing agent and reuptake inhibitor for dopamine and norepinephrine, so 4-FA is kind of a mixture of all three.

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